Historic Charleston, with its antebellum homes and war-torn history, is the belle of this southern-most region. If you’re looking for wildlife, try the ACE basin, named for the Ashepoo, Combahee, and Edisto rivers. Look for Loggerhead sea turtles, storks, and bald eagles. Consider a side trip to historic Fort Sumter, the Citadel, or dine in the resort town of Hilton Head.